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"Hippocampal-dependence
of Anticipatory Neuronal Firing in the Rat Orbitofrontal Cortex" Current theory suggests that the storage of long-term, declarative memories is dependent on interactions between the hippocampal memory system and neocortex. By this view, sensory and behavioral information initially processed in the association neocortex is propagated via convergent projections to the parahippocampal region and the hippocampus (H) that temporarily maintain long-lasting representations in the association cortices. Over time, this long-lasting cortical representation becomes consolidated, meaning that it is no longer dependent on the integrity of the hippocampal system. This project will explore the interaction between one neocortical association area, the orbitofrontal cortex (OF) and the H while rats are performing an olfactory mediated long-term memory task, an odor-sequence learning task. Preliminary work has shown that neurons in the OF show odor-specific firing before the onset of an odor stimulus in a learned sequence. We will demonstrate the H-dependence of this firing by recording from the OF of rats with hippocampal lesions.
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